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Updated: Jul 8, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?
Olga V Smirnova1, Tatiana Yu Ostroukhova, Roman L Bogorad
1Laboratory of Endocrinology, Biological Faculty, M.V. Lomonosov Moscow State University, Leninskie Gory, 1/12, 119992, Moscow, Russia. smirnova_ov@mail.ru
Abstract:
The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development.
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