Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

In situ vaccination, low-dose targeted radionuclide therapy, and immune checkpoint inhibition eradicate poorly immunogenic metastatic tumors in murine cancer models.

Cancer immunology research·2026

Same author

Feasibility and Safety of a Novel CD19-Directed CAR T-Cell Therapy in Patients with R/R B-Cell Non-Hodgkin Lymphoma.

Transplantation and cellular therapy·2026

Same author

Ernest C Borden (1939-2026): in memoriam for a life of caring, researching, leading, teaching and serving.

Journal for immunotherapy of cancer·2026

Same author

Immune-mediated Engagement of T Regulatory Cells with Tumor Cells Results in Trogocytosis and Tumor Cell Killing.

bioRxiv : the preprint server for biology·2025

Same author

Combined innate immune cell therapy, tumor-specific antibody, and radiation prompt antitumor response in pancreatic cancer models.

Science advances·2025

Same author

Divergent role of CD8 T cells with distinct metabolic phenotypes during curative radio-immunotherapy in hot versus cold tumors.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Immunotherapy for pediatric cancer.

Stephan A Grupp¹, Michael Verneris, Paul M Sondel

¹Division of Oncology, Department of Pediatrics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation

|January 1, 2008

Summary

New immune-based therapies offer hope for treating pediatric cancers. These approaches, utilizing T cells, natural killer (NK) cells, and antibodies, may reduce treatment toxicity and improve outcomes for children with difficult-to-treat malignancies.

Related Experiment Videos

Last Updated: Jul 8, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Area of Science:

Pediatric Oncology
Immunotherapy
Cancer Treatment

Background:

Adult cancer survivorship benefits from behavioral changes and screening, but these are not applicable to childhood cancers.
Current pediatric cancer treatments like chemotherapy, radiation, and surgery improve survival but cause significant long-term side effects.
Pediatric oncologists primarily use aggressive therapies to treat, rather than prevent, childhood malignancies.

Purpose of the Study:

To explore the potential of immune-based therapies for treating pediatric malignancies.
To review how T cells, natural killer (NK) cells, and antibodies can be utilized as oncolytic therapies.
To highlight how immunotherapy may overcome treatment resistance and reduce toxicity in pediatric cancer patients.

Main Methods:

Review of current literature on immunotherapy in pediatric oncology.
Exploration of the mechanisms of T cell, NK cell, and antibody-based therapies.
Analysis of the potential benefits and challenges of applying these immune components to pediatric malignancies.

Main Results:

Immune-based therapies represent a novel class of oncolytic treatments for pediatric cancers.
These therapies can target refractory diseases that do not respond to conventional treatments.
Immunotherapy holds the potential to decrease treatment-related toxicities without compromising remission rates.

Conclusions:

Targeted immune-based therapies offer a promising new avenue for treating pediatric malignancies.
Utilizing T cells, NK cells, and antibodies can provide effective oncolytic options with potentially reduced side effects.
Further research and application of immunotherapy are crucial for advancing pediatric cancer care and improving long-term survival.