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Updated: Jul 8, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Multi-centre observational study of buprenorphine use in 32 Italian drug addiction centres
C Leonardi1, N Hanna, P Laurenzi
1District Unit for the Prevention and Treatment of Drug Dependence and Alcoholism, Drug Addiction Centre D/XI-ASL Rome C, Via Appia Antica, 220, 00178 Rome, Italy. leonardiclaudio@jumpy.it
Aim:
To examine how buprenorphine is currently being used across Italy, and to identify simultaneously best practice protocols to guide physicians in optimising the safety and efficacy of this treatment option.
Design:
Retrospective, observational, multi-centre study.
Participants:
A total of 979 opioid-dependent patients were included from 32 centres involving the initiation of 1122 treatments.
Findings:
During the study period 33.4% of patients relapsed during the induction phase. Lower induction doses resulted in markedly higher relapse rates (51.2% of those who received 2 mg versus 20.6% of those who received 10mg of buprenorphine relapsed). Over 89% of patients who received 16 mg of buprenorphine during the induction phase successfully went on to maintenance treatment. The percentage of drug-positive urines also decreased over time on buprenorphine treatment (cocaine-positive urines decreased from 25.8% at study entrance to 0% at 24 months). Psychosocial support in addition to buprenorphine pharmacotherapy further decreased the risk of relapse and was associated with lower levels of heroin craving. Retention in treatment was increased by less-than-daily dosing of buprenorphine.
Conclusions:
Higher induction doses of buprenorphine significantly decreased relapse rates and increased the percentage of patients achieving maintenance treatment. Psychosocial support and/or less-than-daily dosing also appeared to promote positive treatment outcomes.
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