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Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Postmenopausal complete hydatidiform mole: a case report
Faruk Abike1, Osman Temizkan, Ahmet Payasli
1Department of Gynecology and Obstetrics, Sarkikaraagaç State Hospital, Isparta, Turkey. farukabike@gmail.com
Maturitas
|December 29, 2007
Summary
Gestational trophoblastic neoplasia (GTN) is rare in postmenopausal women. This case highlights a benign complete hydatidiform mole in a 56-year-old, emphasizing the need for consideration in postmenopausal diagnoses.
Area of Science:
- Gynecology
- Reproductive Endocrinology
- Oncology
Background:
- Gestational trophoblastic neoplasia (GTN) encompasses a spectrum of placental trophoblastic proliferations, including hydatidiform moles, choriocarcinoma, and others.
- GTN typically affects women of reproductive age, with occurrence in postmenopausal women being exceptionally rare.
Observation:
- A 56-year-old postmenopausal woman presented with symptoms suggestive of GTN, including abdominal pain, nausea, and vomiting.
- Ultrasound revealed an enlarged uterus with complex endometrial changes, and elevated serum beta-human chorionic gonadotropin (beta-HCG) levels (>5000 IU/L).
Findings:
- The patient underwent hysterectomy and bilateral salpingo-oophorectomy.
- Histopathological examination confirmed a complete hydatidiform mole, characterized by hydropic degeneration of chorionic villi and trophoblastic proliferation.
- Post-operative beta-HCG levels normalized to 0 IU/L within 4 weeks.
Implications:
- This case represents one of the few documented instances of a benign complete hydatidiform mole in a postmenopausal woman.
- The findings underscore the importance of considering hydatidiform mole in the differential diagnosis of uterine pathology in postmenopausal patients, despite its rarity.
