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Related Experiment Video

Updated: Jul 8, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

[Congenital transient leukemia: a case report].

V Li-Thiao-Te¹, E Bourges-Petit, J C Capiod

¹Service d'hématologie-oncologie pédiatrique, CHU Nord, place Victor-Pauchet, 80054 Amiens cedex, France. lithiaote.valerie@chu-amiens.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|December 29, 2007

Summary

This summary is machine-generated.

Neonates with Down syndrome have a higher risk of transient leukaemia, a form of congenital leukaemia. This condition, often linked to trisomy 21 in blast cells, typically resolves spontaneously, indicating a good prognosis.

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Last Updated: Jul 8, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Area of Science:

Hematology
Pediatric Oncology
Genetics

Background:

Neonates with Down syndrome exhibit an elevated risk for congenital leukemia, specifically acute megakaryoblastic leukemia (FAB M7).
Transient leukemia, a subtype of congenital leukemia, is frequently observed in infants with Down syndrome and often resolves spontaneously.

Observation:

A case of transient leukemia with an isolated pericardial effusion in a phenotypically normal neonate is presented.
Trisomy 21 was identified in the blast cells of the affected neonate.
The neonate achieved complete remission and remained in remission for 32 months.

Findings:

Congenital leukemia associated with trisomy 21 in blast cells demonstrates a favorable prognosis.
The spontaneous resolution of transient leukemia in neonates with Down syndrome is a key characteristic.

Implications:

The favorable prognosis of congenital leukemia with trisomy 21 supports a watch-and-wait approach before initiating chemotherapy.
This case highlights the importance of recognizing transient leukemia in neonates, even those without constitutional Down syndrome.
Early identification and monitoring can guide treatment decisions, potentially avoiding unnecessary interventions.