Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormesis defined.

Mark P Mattson1

  • 1Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. mattsonm@grc.nia.nih.gov

Ageing Research Reviews
|December 29, 2007
PubMed
Summary
This summary is machine-generated.

Hormesis describes how low doses of stress can benefit cells, while high doses are harmful. Understanding these adaptive responses offers new ways to prevent and treat diseases.

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phytochemicals in Ischemic Stroke.

Neuromolecular medicine·2016
Same author

Corrigendum to "Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity", [Exp. Neurol. 273 (2015), 151-160].

Experimental neurology·2016
Same author

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2.

Cell reports·2016
Same author

Lipid-laden cells differentially distributed in the aging brain are functionally active and correspond to distinct phenotypes.

Scientific reports·2016
Same author

Nuclear DNA damage signalling to mitochondria in ageing.

Nature reviews. Molecular cell biology·2016
Same author

Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis.

Annals of the rheumatic diseases·2016
Same journal

White matter abnormalities in Alzheimer's disease: Implications for pathophysiology, diagnosis, and treatment.

Ageing research reviews·2026
Same journal

Preclinical Evidence for Icariin in Alzheimer's Disease: Methodological Quality, Efficacy, and Mechanisms.

Ageing research reviews·2026
Same journal

The Brain Renin-Angiotensin System in Parkinson's Disease: Friend or Foe? Mechanistic Insights and Therapeutic Implications.

Ageing research reviews·2026
Same journal

Effects of nutritional interventions on biomarkers of cellular senescence in humans: a systematic review.

Ageing research reviews·2026
Same journal

Systemic recalibration and epigenetic resetting as complementary strategies in ageing biology.

Ageing research reviews·2026
Same journal

Macrophage Senescence and Programmed Cell Death in Atherosclerosis: Mechanisms, Cross-Talk, and Emerging Therapeutic Strategies.

Ageing research reviews·2026
See all related articles

Area of Science:

  • Toxicology
  • Cell Biology
  • Molecular Medicine

Background:

  • Hormesis is a biphasic dose-response to environmental agents.
  • It involves adaptive cellular and organismal responses to moderate stress.

Purpose of the Study:

  • To elucidate the cellular signaling pathways and molecular mechanisms of hormesis.
  • To explore novel therapeutic approaches based on hormetic principles.

Main Methods:

  • Review of recent findings on hormesis.
  • Analysis of molecular mediators like kinases, deacetylases, Nrf-2, and NF-kappaB.

Main Results:

  • Hormetic responses involve specific enzymes and transcription factors.
  • Cells upregulate cytoprotective proteins such as growth factors and antioxidant enzymes.

Conclusions:

  • Understanding hormesis mechanisms opens new avenues for disease prevention and treatment.
  • Hormesis offers a framework for developing novel therapeutic strategies.