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Updated: Jul 8, 2026

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
Completion angiography for surgically treated cerebral aneurysms: an economic analysis
Sherman C Stein1, Mark G Burnett, Eric L Zager
1Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA. sherman.stein@uphs.upenn.edu
Routine intraoperative angiography is the most cost-effective method for completion angiography after cerebral aneurysm clipping. This strategy offers better outcomes and lower costs compared to selective or postoperative angiography.
Area of Science:
- Neurosurgery
- Medical Economics
- Radiology
Background:
- Cerebral aneurysms require clipping, a procedure often followed by completion angiography to ensure success.
- Evaluating the cost-effectiveness of different angiography strategies is crucial for optimizing patient care and resource allocation.
Purpose of the Study:
- To compare the cost-effectiveness of various completion angiography strategies following cerebral aneurysm clipping.
Main Methods:
- A comprehensive literature search identified outcome probabilities and costs for different strategies.
- A Markov cost-effectiveness model was employed to compare quality-adjusted life-years and costs.
- Sensitivity analyses and Monte Carlo simulations were utilized to assess model variability.
Main Results:
- Routine intraoperative angiography was found to be more cost-effective than selective intraoperative angiography (less costly, more effective).
- Routine postoperative angiography was the least cost-effective strategy.
- Selective angiography may be considered in centers with exceptionally low rates of clip-induced arterial compromise.
Conclusions:
- Routine intraoperative angiography is the most cost-effective completion angiography method currently available after cerebral aneurysm clipping.
- The findings support the widespread adoption of routine intraoperative angiography for improved outcomes and efficiency.
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