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Related Concept Videos

Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
Ethnic Identity within a Larger Culture01:27

Ethnic Identity within a Larger Culture

Adolescents from ethnic minority backgrounds face a multifaceted journey in forming their identities, shaped by the intersections of cultural expectations and personal exploration. For these adolescents, identity formation involves not only typical developmental challenges but also navigating the perceptions and attitudes of the majority culture. As they grow, adolescents in ethnic minority groups often become increasingly aware of stereotypes, social biases, and discrimination, all of which...
The Role of Culture01:23

The Role of Culture

Culture plays a crucial role in shaping self-identity and influencing thought and behavior, a foundational interest within social psychology. The multicultural perspective recognizes that individuals do not exist in a vacuum; instead, their experiences, perceptions, and actions are deeply influenced by the intersecting dimensions of their cultural, ethnic, and social group affiliations.Cultural Influence on Self-Identity and Social PerceptionCultural frameworks inform how individuals define...
Self-Esteem and Culture01:26

Self-Esteem and Culture

Self-esteem, a core psychological construct, is intricately shaped by cultural context and varies significantly between collectivist and individualistic societies. In collectivist cultures such as Japan, self-esteem tends to be flexible, context-sensitive, and influenced by relationships. A Japanese student, for instance, may show restraint in formal settings like school but behave more openly among close friends, reflecting the flexible and dynamic nature of self-concept in such...
Close Relationships and Culture01:29

Close Relationships and Culture

Culture shapes how people approach attraction, choose partners, and build long-term relationships. While some preferences in mate selection appear consistent across cultures, such as men valuing physical attractiveness and women emphasizing financial resources, cultural contexts influence how these preferences are expressed and prioritized. Marriage extends beyond romantic ideals in many societies and is deeply embedded in social, economic, and religious frameworks.The Role of Culture in Mate...
Self Within Cultural Contexts01:30

Self Within Cultural Contexts

Cultural frameworks for understanding the self are often categorized into two broad orientations: individualism and collectivism. These paradigms influence how people define themselves, relate to others, and interpret their social worlds. Each orientation offers distinct perspectives on autonomy, responsibility, and the role of the individual within a community.Individualistic CulturesIn individualistic cultures like North America and Western Europe, identity is understood as autonomous and...

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Incidence of Posttransplantation Diabetes Mellitus in De Novo Kidney Transplant Recipients Receiving Prolonged-Release Tacrolimus-Based Immunosuppression With 2 Different Corticosteroid Minimization Strategies: ADVANCE, A Randomized Controlled Trial.

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In memoriam--Carl-Gustav Groth 1933-2014.

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Related Experiment Video

Updated: Jul 8, 2026

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

The European experience.

Gunnar Tydén1

  • 1Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden. gunnar.tyden@karolinska.se

Transplantation
|January 25, 2008
PubMed
Summary

A new protocol for ABO-incompatible kidney transplants, using antigen-specific immunoadsorption and rituximab, shows excellent outcomes. This method achieved no graft losses related to ABO incompatibility in a recent study.

Area of Science:

  • Nephrology
  • Immunology
  • Transplantation

Background:

  • ABO-incompatible kidney transplantation was historically challenging due to pre-formed antibodies.
  • A novel protocol was developed in 2001 to overcome these barriers.

Purpose of the Study:

  • To evaluate the efficacy and safety of a new protocol for ABO-incompatible kidney transplantation.
  • To assess graft and patient survival rates compared to ABO-compatible transplants.

Main Methods:

  • The protocol involves antigen-specific immunoadsorption, rituximab, and standard immunosuppression (tacrolimus, mycophenolate mofetil, prednisolone).
  • Data from nearly 200 procedures across multiple European centers were analyzed.
  • A 3-center pooled analysis included 60 consecutive ABO-incompatible living-donor transplantations.

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Main Results:

  • No graft losses were attributed to ABO incompatibility in the analyzed cohort.
  • Graft survival rates were comparable to those in ABO-compatible kidney transplantations.
  • Patient survival rates were also similar between ABO-incompatible and ABO-compatible groups.

Conclusions:

  • The described protocol is effective in managing ABO-incompatible kidney transplantation.
  • This approach offers comparable graft and patient survival to ABO-compatible transplantation.
  • The protocol has been successfully implemented across numerous European centers since 2001.