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Related Experiment Video

Updated: Jul 8, 2026

Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined Workflow

Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined Workflow

Published on: January 8, 2014

Present techniques for antibody removal.

Gunnar Tydén¹, Gunilla Kumlien, Mats Efvergren

¹Department of Transplantation Surgery, Karolinska University Hospital, Stockholm, Sweden. gunnar.tyden@karolinska.se

Transplantation

|January 25, 2008

Summary

Kidney transplants with positive antibody tests face rejection. Antibody removal techniques like plasmapheresis and immunoadsorption are crucial for successful renal transplantation. This review covers current antibody removal methods.

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Last Updated: Jul 8, 2026

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Published on: September 14, 2018

Area of Science:

Nephrology
Immunology
Transplantation Science

Background:

Positive cytotoxic cross-match or ABO-incompatible blood groups lead to acute humoral rejection in renal transplantation.
Pre-transplant removal of Human Leukocyte Antigen (HLA) and anti-A/B antibodies is essential to prevent rejection.

Purpose of the Study:

To review currently available techniques for antibody removal in renal transplantation.
To highlight methods for preventing acute humoral rejection in high-risk transplant recipients.

Main Methods:

Review of existing literature on antibody removal procedures.
Focus on plasmapheresis and immunoadsorption as primary techniques.

Main Results:

Plasmapheresis and immunoadsorption are the most common methods for removing HLA and anti-A/B antibodies.
These techniques are vital for enabling renal transplantation in patients with positive cross-matches or incompatible blood groups.

Conclusions:

Effective antibody removal is a prerequisite for successful renal transplantation in sensitized patients.
Plasmapheresis and immunoadsorption represent key strategies in managing antibody-mediated rejection risks.