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Medical therapy: options and uses.

John D Carmichael1, Vivien S Bonert

  • 1Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Reviews in Endocrine & Metabolic Disorders
|December 29, 2007
PubMed
Summary

Medical treatments for acromegaly have advanced, offering effective options like somatostatin receptor ligands and growth hormone receptor antagonists to control excess growth hormone and tumor size.

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Area of Science:

  • Endocrinology
  • Oncology

Background:

  • Acromegaly results from growth hormone-producing tumors.
  • Medical treatments have evolved significantly, offering diverse therapeutic options.

Purpose of the Study:

  • To review current medical treatment options for acromegaly.
  • To discuss the efficacy and role of different drug classes in managing acromegaly.

Main Methods:

  • Review of current medical therapies for acromegaly.
  • Analysis of somatostatin receptor ligands, growth hormone receptor antagonists, and dopamine agonists.
  • Discussion of the established and potential roles of medical therapy.

Main Results:

  • Somatostatin receptor ligands are effective in ~60% of patients, reducing growth hormone and tumor volume.
  • Growth hormone receptor antagonists show high efficacy (up to 97%) but require more long-term safety data.
  • Dopamine agonists are cost-effective but less efficacious than other options.

Conclusions:

  • Medical therapy is crucial as adjuvant or primary treatment for acromegaly.
  • Combination therapies and pre-surgical treatments show promise but need further validation.
  • Current therapies can achieve disease control in nearly all acromegaly patients.