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Mid-infrared optical coherence tomography.

Christopher S Colley1, Jeremy C Hebden, David T Delpy

  • 1Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, Gower Street, London WC1E 6BT, United Kingdom.

The Review of Scientific Instruments
|January 1, 2008
PubMed
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This study introduces the first time domain optical coherence tomography (OCT) system operating in the mid-infrared, enabling molecular imaging of bioengineered tissues without contrast agents.

Area of Science:

  • Biomedical Optics
  • Biophotonics
  • Tissue Engineering

Background:

  • Optical Coherence Tomography (OCT) is a valuable imaging modality for biological tissues.
  • Existing OCT systems primarily operate in the near-infrared, limiting biochemical composition analysis.
  • Characterizing bioengineered tissues requires detailed structural and molecular information.

Purpose of the Study:

  • To develop and demonstrate a novel time domain optical coherence tomography (OCT) system operating in the mid-infrared spectral region (6-8 microm).
  • To enable label-free optical coherence molecular imaging of bioengineered tissues by leveraging the mid-infrared fingerprint region.
  • To characterize bioengineered tissues based on their structural and biochemical composition.

Main Methods:

  • Development of a free-space Michelson interferometer incorporating a germanium beam splitter and a liquid nitrogen-cooled HgCdTe detector.

Related Experiment Videos

  • Creation of a broadband quantum cascade laser source emitting continuously from 6-8 microm.
  • Implementation of time domain optical coherence tomography (OCT) principles in the mid-infrared.

    • Main Results:

    • Successful operation of the first reported mid-infrared OCT system.
    • Demonstration of a broadband quantum cascade laser source covering the 6-8 microm range.
    • Preliminary measurements showcasing the potential for molecular imaging.

    Conclusions:

    • The developed mid-infrared OCT system offers a new capability for label-free molecular imaging of bioengineered tissues.
    • The system utilizes the "mid-infrared fingerprint region" for inherent molecular specificity.
    • This technology has the potential to advance the characterization of bioengineered constructs.