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Three-dimensional Optical-resolution Photoacoustic Microscopy

Three-dimensional Optical-resolution Photoacoustic Microscopy

Published on: May 3, 2011

Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system.

Chao-Kang Liao¹, Sheng-Wen Huang, Chen-Wei Wei

¹National Taiwan University, Department of Electrical Engineering, Taipei 106, Taiwan.

Journal of Biomedical Optics

|January 1, 2008

Summary

This study introduces a new photoacoustic imaging method using gold nanorods to measure blood flow. The technique accurately quantifies flow velocities in biological tissues.

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Area of Science:

Biomedical Optics
Photoacoustic Imaging
Nanotechnology

Background:

Quantitative flow measurement is crucial in biomedical applications.
Photoacoustic imaging offers high contrast and resolution for biological tissues.
Gold nanorods serve as effective contrast agents due to tunable optical properties.

Purpose of the Study:

To develop and validate a novel quantitative flow measurement method using photoacoustic imaging.
To utilize laser-induced changes in gold nanorod properties for flow estimation.
To assess the accuracy of the method in biological tissue samples.

Main Methods:

A quantitative flow measurement technique employing sequential photoacoustic images.
Use of gold nanorods as contrast agents, with laser irradiation altering their aspect ratio and optical absorption.

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Three-dimensional Optical-resolution Photoacoustic Microscopy

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Blood Flow Imaging with Ultrafast Doppler

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

A custom-designed, high-frame-rate photoacoustic imaging system with a 64-element transducer array.

Monitoring nanorod concentration changes influenced by laser-induced shape modifications and flow-dependent replenishment.

Main Results:

The developed method successfully estimated wash-in flow.
Experimental results in chicken breast tissue demonstrated flow velocity measurements from 0.125 to 2 mm/s.
An average error of 31.3% was achieved in flow velocity measurements.

Conclusions:

The described photoacoustic flow measurement method using gold nanorods is feasible.
The system can quantify flow velocities in biological tissues with reasonable accuracy.
This technique holds potential for various biomedical flow monitoring applications.