Related Experiment Video
Updated: Jul 8, 2026

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
Published on: June 21, 2024
Mixed gonadal dysgenesis and Denys-Drash syndrome: urologists should screen for nephrotic syndrome
Oleg Shapiro1, Thomas R Welch, Maryellen Sheridan
1State University of New York, Upstate Medical University, Department of Urology, Syracuse, New York, USA.
Objective:
We present a child with Denys-Drash syndrome recognized after surgery for mixed gonadal dysgenesis, and discuss screening procedures the urologist should consider in similar circumstances.
Case Report:
A 1-year-old child with XY gonadal dysgenesis underwent genital reconstruction. The postoperative period was complicated by incisional drainage, which led to the recognition of a nephrotic syndrome. Molecular analysis of the WT-1 gene confirmed a mutation associated with the Denys-Drash syndrome.
Conclusion:
The Denys-Drash syndrome should be suspected in children with XY gonadal dysgenesis. The presence of urine protein should be sought in such children, and if present, consultation with genetic and nephrology specialists is warranted.
Related Concept Videos
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Nursing Assessment of the Genitourinary System I: Health History
Nephrotic Syndrome III : Nursing Management
Nursing Assessment of the Genitourinary System II: Inspection and Palpation
Disorders of the Urinary System
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...

