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Updated: Jul 8, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
Published on: January 24, 2016
The interferon signaling network and transcription factor C/EBP-beta
Hui Li1, Padmaja Gade, Weihua Xiao
1Department of Microbiology & Immunology, Greenebaum Cancer Center, University of Maryland School of Medicine, 660 W. Redwood Street, Baltimore, MD 21201, USA.
Abstract:
Cytokines like interferons (IFNs) play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-beta in mediating these responses.
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