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Related Experiment Video

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Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

Published on: February 20, 2015

Epithelial cell apoptosis and lung remodeling.

Kazuyoshi Kuwano¹

¹Division of Respiratory Diseases, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. kkuwano@jikei.ac.jp

Cellular & Molecular Immunology

|January 1, 2008

Summary

Epithelial cell apoptosis initiates lung damage and remodeling in lung diseases. Understanding apoptosis pathways offers potential for novel therapeutic strategies targeting these conditions.

Area of Science:

Cell Biology
Pulmonology
Pathology

Background:

Lung epithelial cells are central to lung damage in various diseases.
Epithelial cell apoptosis is an early event in many lung pathologies.
Apoptosis involves direct death receptor and stress-induced mitochondrial/endoplasmic reticulum pathways.

Purpose of the Study:

To review recent advances in understanding apoptosis signaling in the lung.
To discuss the role of apoptosis in lung remodeling processes.

Main Methods:

Literature review of apoptosis signaling pathways.
Analysis of epithelial and mesenchymal interactions in lung remodeling.

Main Results:

Apoptosis signaling comprises direct and stress-mediated pathways.

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Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells

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Generation of Lymphocytic Microparticles and Detection of their Proapoptotic Effect on Airway Epithelial Cells

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Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells

Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells

Published on: March 6, 2020

Epithelial cell death triggers complex remodeling including fibrosis.

Epithelial-mesenchymal interactions are critical in lung repair and disease.

Conclusions:

Further insights into apoptosis regulation may yield new lung disease treatments.
Targeting apoptosis pathways is a promising therapeutic avenue for lung diseases.