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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Related Experiment Video

Updated: Jul 8, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Wnt signaling and skeletal development.

Fei Liu1, Sean Kohlmeier, Cun-Yu Wang

  • 1Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.

Cellular Signalling
|January 1, 2008
PubMed
Summary
This summary is machine-generated.

Wnt signaling pathways are crucial for skeletal biology, influencing bone mass. This review details the roles of both canonical and non-canonical Wnt signaling in bone development.

More Related Videos

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Related Experiment Videos

Last Updated: Jul 8, 2026

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Area of Science:

  • Skeletal Biology and Cellular Signaling

Background:

  • Wnt proteins are secreted signaling molecules regulating cellular functions.
  • Mutations in low-density lipoprotein receptor-related protein 5 (LRP5) impact human bone mass, highlighting Wnt signaling's skeletal relevance.
  • Both canonical and non-canonical Wnt pathways are increasingly recognized for their roles in skeletal development.

Purpose of the Study:

  • To review the current understanding of Wnt signaling in skeletal development.
  • To discuss the involvement of Wnt signaling in chondrogenesis, osteoblastogenesis, and osteoclastogenesis.

Main Methods:

  • Literature review of Wnt signaling in skeletal biology.
  • Analysis of studies on canonical and non-canonical Wnt pathways.
  • Synthesis of findings on Wnt roles in chondrocytes, osteoblasts, and osteoclasts.

Main Results:

  • Canonical Wnt signaling plays a significant role in various aspects of skeletal development.
  • Non-canonical Wnt signaling also contributes importantly to skeletal development.
  • Wnt signaling influences key cellular processes including chondrogenesis, osteoblastogenesis, and osteoclastogenesis.

Conclusions:

  • Wnt signaling is a critical regulator of skeletal development.
  • Understanding Wnt pathways offers potential therapeutic targets for bone diseases.
  • Further research into non-canonical Wnt signaling in the skeleton is warranted.