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Goserelin versus leuprolide before hysterectomy for uterine fibroids
Soo Soo Lim1, Jayanthi K Sockalingam, Peng Chiong Tan
1Department of Obstetrics and Gynecology, University of Malaya, Kuala Lumpur, Malaysia.
Objective:
To compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri.
Methods:
A randomized study of 66 premenopausal women with fibroid uteri at least 14 weeks of gestation in a gravid uterus. Women were randomized to receive either subcutaneous depot 3.6 mg goserelin or 3.75 mg leuprolide every 4 weeks for a total of 3 doses. Hysterectomy was performed within 1 month of the last dose.
Results:
A total of 34 women randomized to the goserelin group and 31 women to the leuprolide group were available for analysis. Preoperative hemoglobin level (P=0.89), operative blood loss (P=0.72), and operating time (P=0.39) were not different between the 2 groups. Postoperative hemoglobin was higher in the leuprolide group (P=0.003), but blood transfusion requirement was not different between the groups (P=1.0). Other outcomes and side effects of the drugs were similar.
Conclusions:
Goserelin and leuprolide administered before hysterectomy for uterine fibroids have similar perioperative outcomes.