Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Complement 3 in hypertension and arteriosclerosis].

G S Kurochkin, G G Arabidze, A A Liakishev

    Kardiologiia
    |December 1, 1991
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Russian Medical Society for Arterial Hypertension expert consensus. Resistant hypertension: detection and management].

    Terapevticheskii arkhiv·2022
    Same author

    [Topical issues of adequate control of dyslipidemia in the prevention of acute and recurrent cerebral circulatory disorders of ischemic type].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2022
    Same author

    [Comparative capabilities of the speckle-tracking echocardiography technologiesin two-dimensional and three-dimensional modes in the detection of subclinical cardiotoxicity in patients with breast cancer].

    Terapevticheskii arkhiv·2021
    Same author

    [Clinical characteristics and quality assessment of the treatment of patients with chronic heart failure with diabetes mellitus].

    Terapevticheskii arkhiv·2020
    Same author

    Arterial hypertension and chronic obstructive pulmonary disease: clinical characteristics and treatment efficasy (according to the national register of arterial hypertension).

    Terapevticheskii arkhiv·2019
    Same author

    [Progress and Problems of Practical Cardiology in Russia at the Present Stage].

    Kardiologiia·2019
    Same journal

    [Clinical Case of Using Inclisiran in a Patient with End-Stage Renal Disease, Before and After Kidney Transplantation].

    Kardiologiia·2026
    Same journal

    Cardiometabolic and Antioxidant Properties of Modified C-Terminal Fragments of Apelin in Experimental Cardiac Pathology.

    Kardiologiia·2026
    Same journal

    Peroxisome Biogenesis Factor 10 Upregulation Promotes Cardiomyocyte Ferroptosis and Glutathione Peroxidase 4 Repression During Myocardial Ischemia-Reperfusion Injury.

    Kardiologiia·2026
    Same journal

    Diagnostic Value and Prognostic Assessment of Exercise Stress Echocardiography in Patients With Suspected Coronary Artery Disease Without Typical Angina Symptoms.

    Kardiologiia·2026
    Same journal

    Early Post-discharge Glycemic Control and Cardiovascular Event Readmission in Patients With Heart Failure and Type 2 Diabetes: A Single-center Retrospective Cohort Study.

    Kardiologiia·2026
    Same journal

    Microcirculatory Features of the Conjunctiva and Retina in Patients with Stable Ischemic Heart Disease and Various Patterns of Coronary Artery Involvement.

    Kardiologiia·2026
    See all related articles

    Individuals with the C3F allotype may experience faster coronary atherosclerosis progression, especially when hypertension is also present. This genetic factor impacts complement component 3 activity and disease severity.

    Area of Science:

    • Immunogenetics
    • Cardiovascular Disease Research
    • Complement System Biology

    Background:

    • Hypertensive disease (HD) and coronary atherosclerosis (CA) are significant cardiovascular risks.
    • The complement system, particularly complement component 3 (C3), plays a role in inflammatory processes relevant to cardiovascular health.
    • Genetic variations, such as C3 allotypes, may influence disease susceptibility and progression.

    Purpose of the Study:

    • To investigate the association between C3 allotypes, serum C3 levels, and residual functional activity (RFA) in patients with hypertensive disease and/or coronary atherosclerosis.
    • To determine if the C3F allotype is linked to an increased risk or accelerated progression of cardiovascular conditions.
    • To explore differences in C3 parameters between patient groups and healthy controls.

    Related Experiment Videos

    Main Methods:

    • Serum samples were collected from patients with HD, CA, HD + CA, and healthy controls.
    • Measurements included serum C3 concentrations, C3 residual functional activity (RFA), and C3 allotype phenotyping.
    • Statistical analyses were performed to compare groups and identify significant associations.

    Main Results:

    • A higher frequency of the C3F allotype was observed in patients with HD, CA, and HD + CA compared to controls.
    • The combined HD + CA group exhibited a significant decrease in C3 RFA compared to the HD and CA groups alone.
    • Significant differences in serum C3 concentrations and RFA were found in C3F carriers between CA and HD patients.

    Conclusions:

    • Carriage of the C3F allotype may predispose individuals to accelerated coronary atherosclerosis progression, particularly in the context of hypertensive disease.
    • C3 RFA is significantly reduced in patients with both HD and CA, suggesting a role for complement dysfunction in combined disease states.
    • The C3F allotype represents a potential genetic risk factor influencing the interplay between hypertension and atherosclerosis.