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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

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Deep brain stimulation for psychiatric disorders.

Paul Sloan Larson¹

¹Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA. larsonp@neurosurg.ucsf.edu

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics

|January 1, 2008

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) revitalizes surgical options for psychiatric disorders like Tourette's syndrome, obsessive-compulsive disorder, and major depression. This review examines DBS targets and discusses future challenges for this evolving field.

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Area of Science:

Neurosurgery
Psychiatry
Neurology

Background:

Historically, surgical interventions for psychiatric conditions were limited.
The advent of deep brain stimulation (DBS) has renewed interest in surgical treatments.
DBS offers potential advantages over older lesioning techniques.

Purpose of the Study:

To critically review major deep brain stimulation (DBS) targets for Tourette's syndrome, obsessive-compulsive disorder, and major depression.
To discuss current and future challenges in applying DBS to psychiatric disorders.
To propose 'limbic disorders surgery' as a parallel to movement disorders surgery.

Main Methods:

Literature review of major DBS targets in psychiatric disorders.
Analysis of current challenges and future directions for DBS in psychiatry.
Comparative analysis with surgical approaches for movement disorders.

Main Results:

Identified key DBS targets currently under investigation for Tourette's syndrome, OCD, and major depression.
Highlighted significant challenges in the clinical application and advancement of psychiatric DBS.
Established parallels between DBS for psychiatric and movement disorders.

Conclusions:

Deep brain stimulation (DBS) represents a promising frontier in the surgical management of severe psychiatric disorders.
Further research and refinement of targets are necessary to overcome current challenges.
The field may benefit from a unified nomenclature, such as 'limbic disorders surgery'.