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Updated: Jul 8, 2026
11:25
Quantitative Analysis of Protein Expression to Study Lineage Specification in Mouse Preimplantation Embryos
Published on: February 22, 2016
Cell cycle regulation during early mouse embryogenesis
Jérôme Artus1, Michel Cohen-Tannoudji
1Unité de Génétique Fonctionnelle de la souris, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. artusj@mskcc.org
Molecular and Cellular Endocrinology
|January 1, 2008
Summary
Early mouse embryonic development involves cell cycle plasticity. This review summarizes how cell cycle regulation mechanisms in vivo impact development, using mutant mouse studies.
Area of Science:
- Developmental Biology
- Cell Biology
- Genetics
Background:
- Multicellular organism development requires coordinated proliferation and developmental processes.
- Embryonic cell cycle plasticity is high, but in vivo regulation mechanisms are poorly understood.
Purpose of the Study:
- To review cell cycle regulation during early mouse embryonic development.
- To analyze the role of cell cycle parameters in developmental transitions.
- To discuss the contribution of cell cycle regulators to developmental programs.
Main Methods:
- Review of existing literature on cell cycle regulation in early mouse embryos.
- Analysis of data from mutant mouse studies investigating in vivo cell cycle control.
- Discussion of the interplay between cell cycle regulators and developmental pathways.
Main Results:
- Early embryonic development shows significant cell cycle variations linked to developmental transitions.
- Mutant mouse models provide crucial insights into in vivo cell cycle regulation.
- Specific cell cycle regulators are implicated in directing developmental programs.
Conclusions:
- Understanding in vivo cell cycle regulation is vital for comprehending embryonic development.
- Cell cycle plasticity is a key feature of early development, influenced by specific regulators.
- Future research should further elucidate the precise roles of cell cycle regulators in developmental processes.
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