Related Experiment Video
Updated: Jul 8, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
The therapy of multiple sclerosis with immune-modulating or immunosuppressive drug. A critical evaluation based upon
Marinella Clerico1, Chiara Rivoiro, Giulia Contessa
1Dipartimento di Scienze Cliniche e Biologiche, Divisione di Neurologia, Ospedale Universitario, S.Luigi Gonzaga, Universita' di Torino, Torino, Italy.
Abstract:
Today many different drugs are available for treatment of multiple sclerosis (MS). Interferons, glatiramer acetate, mitoxantrone, and natalizumab have been approved by the regulatory authorities of many countries for the treatment of MS. Evidence based medicine (EBM) principles allow physicians to better address the correct treatment for patients. This article aimed to review all the clinical trials on immune-modulating and immunosuppressive drugs on the basis of the EBM principles. Based on the evidence to date interferon beta represents the best therapeutic option, particularly if given at high doses and with multiple injections per week. Due to its lower efficacy, glatiramer acetate should be used as a second choice in case of intolerable side effects or toxicity of interferon beta. Great efficacy has been demonstrated for mitoxantrone and natalizumab. These drugs should be, however, used with particular attention for their potential toxic effects.
Related Concept Videos
Multiple Sclerosis l: Introduction
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Tumor Immunotherapy
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Therapeutic Drug Monitoring: Affecting Factors
Drug Therapy
Antianxiety Medications

