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Peripheral quantitative computed tomography of the tibia: pediatric reference values.

Laurie J Moyer-Mileur1, Jody L Quick, Mary A Murray

  • 1Center for Pediatric Nutrition Research, University of Utah, Salt Lake City, UT 84158, USA. laurie.moyer-mileur@hsc.utah.edu

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|January 1, 2008
PubMed
Summary
This summary is machine-generated.

This study establishes normal reference ranges for peripheral quantitative computed tomography (pQCT) measurements of the tibia in children. These findings provide crucial data for assessing bone health and development in pediatric populations.

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Area of Science:

  • Pediatric Bone Health
  • Skeletal Development
  • Medical Imaging

Background:

  • Peripheral quantitative computed tomography (pQCT) is utilized in pediatric research.
  • Existing reference data for children using pQCT is mainly limited to the radius bone.
  • There is a need for normative data specific to the tibia in pediatric populations.

Purpose of the Study:

  • To establish normal reference ranges for pQCT measurements of the tibia in healthy children.
  • To assess bone geometry, density, and strength at the distal tibia metaphysis and diaphysis.
  • To provide gender-specific and height-specific reference data for pediatric tibia pQCT analysis.

Main Methods:

  • A cross-sectional study involving 416 healthy, white, non-Hispanic children aged 5-18 years.
  • pQCT measurements were taken at the distal tibia metaphysis (trabecular bone) and diaphysis (cortical bone).
  • Statistical analyses were performed to determine gender and height differences, and to generate height-specific centile curves.

Main Results:

  • A significant positive linear relationship was observed between tibia cortical bone geometry/strength and height (r2 >or=0.58, p<0.001).
  • Boys exhibited greater mean values for tibia cortical bone geometry and strength compared to girls (p
  • Trabecular volumetric bone mineral density was higher in boys than girls, independent of height or age (p

Conclusions:

  • The study successfully generated reference data for pQCT analysis of the pediatric tibia.
  • These data enhance the evaluation of bone size, geometry, and strength in children.
  • pQCT serves as a valuable tool for assessing bone health in young individuals.