Structure-reactivity relationships for electrophilic sugars in interaction with nucleophilic biological targets
Paola R Campodónico1, Renato Contreras
1Instituto de Ciencias, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, código postal 771-0162, Santiago, Chile. pcampodonico@udd.cl
Bioorganic & Medicinal Chemistry
|January 1, 2008
Abstract:
The global electrophilicity index that incorporates electrostatic and polarizability contributions shows a quantitative correlation with antiviral and cytotoxic activities of electrophilic sugars. The model is applied to a series of compounds that behave as Michael acceptors in interaction with biological nucleophilic targets.
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