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Updated: Jul 8, 2026

Modeling Cataract Surgery in Mice

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Published on: December 1, 2023

Megalocornea and bilateral developmental cataracts.

Antonella Berry-Brincat¹, Tin K J Chan

¹Eye Department, Royal Hallamshire Hospital, Sheffield, United Kingdom. aberrybrincat@hotmail.com

Journal of Cataract and Refractive Surgery

|January 1, 2008

Summary

Cataract surgery in children with megalocornea is challenging, often leading to intraocular lens (IOL) decentration and posterior capsule opacification. Careful consideration of IOL type and size is crucial for successful outcomes.

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Area of Science:

Ophthalmology
Pediatric Ophthalmology
Cataract Surgery

Background:

Megalocornea is a rare congenital condition characterized by an enlarged cornea.
Juvenile cataracts can occur in children and may require surgical intervention.
Cataract extraction in pediatric patients presents unique surgical challenges.

Observation:

A 9-year-old boy with megalocornea and juvenile cataracts underwent bilateral lens aspiration and intraocular lens (IOL) implantation.
Postoperatively, both IOLs demonstrated gradual decentration.
Posterior capsule opacification developed, necessitating neodymium:YAG (Nd:YAG) laser capsulotomy.

Findings:

Despite IOL decentration and posterior capsule opacification, the patient's vision remained stable with glasses five years after Nd:YAG capsulotomy.
Cataract extraction in the context of megalocornea is associated with a high frequency of complications.
The management of pediatric cataracts in megalocornea requires careful selection of IOL type and size.

Implications:

This case highlights the complexities of managing cataracts in children with megalocornea.
Ophthalmologists must carefully weigh the risks and benefits of IOL implantation in such cases.
Further research into optimal surgical techniques and IOLs for megalocornea is warranted.