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Related Experiment Video

Updated: Jul 8, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Chronic pediatric inflammatory diseases: effects on bone.

Anuradha Viswanathan¹, Francisco A Sylvester

¹University of Connecticut School of Medicine, Farmington, CT, USA. Aviswanathan@ccmckids.org

Reviews in Endocrine & Metabolic Disorders

|January 1, 2008

Summary

Chronic inflammatory diseases in children can negatively impact bone health, leading to reduced bone mass and increased fracture risk. This overview examines the effects on skeletal development and potential interventions.

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Last Updated: Jul 8, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

Pediatric rheumatology
Pediatric endocrinology
Pediatric bone health

Background:

Chronic inflammatory diseases (CIDs) pose a significant threat to long-term skeletal health in children.
CIDs are linked to poor nutrition, altered nutrient use, delayed puberty, inactivity, and reduced muscle mass, all impacting bone metabolism.
The immune response in CIDs directly affects bone cell activity, further compromising skeletal integrity.

Purpose of the Study:

To provide a comprehensive overview of how chronic inflammatory conditions affect bone mass in children.
To explore the pathogenesis of decreased bone mass in pediatric inflammatory diseases.
To include relevant data from adult patients where pediatric data are limited.

Main Methods:

Review of existing literature, primarily focusing on studies utilizing dual-energy X-ray absorptiometry (DXA).
Analysis of factors contributing to altered bone metabolism in children with CIDs.
Inclusion of adult patient data to supplement pediatric findings when necessary.

Main Results:

Deficits in bone mass are commonly observed in children with CIDs, as documented by DXA studies.
Wide variations in low bone mass prevalence exist, influenced by study population characteristics.
Glucocorticoid therapy, often used for CIDs, can negatively impact bone formation and linear growth.

Conclusions:

Children with CIDs are at risk of not achieving predicted peak bone mass, increasing short-term and future fracture risk.
Understanding the multifactorial impact of CIDs on bone health is crucial for effective management.
Further research is needed to optimize bone health strategies for pediatric patients with chronic inflammatory conditions.