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Microscopic colitis-defining incidence rates and risk factors: a population-based study

Jennifer J Williams1, Gilaad G Kaplan, Sapna Makhija

  • 1Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|January 2, 2008
PubMed
Abstract

Insights

Microscopic colitis (MC) incidence in North America is 10.0 per 100,000 person-years. Risk factors include older age, female sex, malignancy, celiac disease, and hypothyroidism.

Area of Science:

  • Gastroenterology
  • Epidemiology

Background:

  • Microscopic colitis (MC) burden and determinants in North America require definition.
  • This study aimed to determine MC incidence and risk factors in a North American population.

Purpose of the Study:

  • To establish the incidence rate of microscopic colitis (MC) in North America.
  • To identify key risk factors associated with developing MC.

Main Methods:

  • A population-based cohort study was conducted from April 2002 to March 2004.
  • Pathologic MC diagnoses were identified, and chart reviews confirmed diagnoses and risk factors.
  • Risks were reported as rate ratios (RRs) with 95% confidence intervals (CIs).

Main Results:

  • The annual incidence rate of MC was 10.0 per 100,000 person-years (lymphocytic colitis: 5.4; collagenous colitis: 4.6).
  • Individuals over 65 were over 5 times more likely to develop MC (RR, 5.6).
  • Women, celiac disease, hypothyroidism, and malignancy were associated with increased MC risk.

Conclusions:

  • Incidence rates align with previous North American and European population-based studies.
  • An increased incidence of MC was observed in specific disease states.
  • A novel finding indicates an increased risk of MC associated with malignancy.

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