Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bionic organs.

P M Galletti1

  • 1Brown University, Division of Biology and Medicine, Providence, Rhode Island 02912.

Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgie
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Bionic organ science aims to regenerate lost human tissues using advanced polymer membranes and novel materials. This technology could enable nerve regrowth and treat conditions like diabetes and Parkinson's disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue engineering: from basic science to products: a preface.

Tissue engineering·2009
Same author

Discussion of paper by bert k. Kusserow, m.d.: use of pathologic techniques in the evaluation of emboli from prosthetic devices.

Bulletin of the New York Academy of Medicine·2009
Same author

The AIMBE President's session: medical device innovation and the public interest.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·1997
Same author

Controlled delivery of therapeutics from microporous membranes. I. Fabrication and characterization of microporous polyurethane membranes containing polymeric microspheres.

Biomaterials·1997
Same author

Biomaterials availability in the U.S.

Journal of biomedical materials research·1996
Same author

Penetrating micropores increase patency and achieve extensive endothelialization in small diameter polymer skin coated vascular grafts.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·1996

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Unlike lizards, humans cannot regenerate complex organs or tissues like kidneys, nerves, or spinal cords.
  • Current medical limitations prevent restoration of function after severe tissue damage or loss.

Purpose of the Study:

  • To explore the potential of bionic organ science in regenerating damaged human tissues and organs.
  • To overcome current therapeutic limitations in treating conditions involving tissue loss or dysfunction.

Main Methods:

  • Utilizing ultra-thin, biocompatible, selectively permeable polymer membranes for immune protection and solute exchange.
  • Synthesizing novel biostable and bioresorbable materials as scaffolding for controlled tissue regrowth.
  • Combining materials science, cell biology, and experimental surgery for fabricating tissue-polymer composites.

Related Experiment Videos

Main Results:

  • Demonstrated fabrication, growth, and survival of tissue-polymer composites in tissue culture.
  • Extended in vivo studies to experimental models of endocrine deficiency and neurological defects.
  • Identified key technological achievements in polymer membranes and synthetic scaffolding materials.

Conclusions:

  • Bionic organ science holds promise for regenerating tissues and improving function in conditions like paralysis and diabetes.
  • Progress hinges on the integration of materials science, cell biology, and surgical techniques.
  • Clinical implementation faces challenges including tissue sourcing, safety verification, and manufacturing scalability.