[Microsurgical arterial prostheses in tissue pretreated with Cisplatin]

Female WAG-Rij rats (160-180 g b.w.) were treated with Cisplatin (12.6 mg/kg b.w.) over 3 weeks. After chemotherapy a homologous freeze-dried carotid segment of 4 mm length was grafted in the right carotid artery. The evolution of the new prosthesis endothelium was observed by SEM. 4 weeks after the microsurgical treatment, the healing process and reendothelialization of the prosthesis was concluded in the control group. In the cisplatin group endothelial damages and irregularities of the pseudointima of the freeze-dried graft were found up to the sixth week after surgery. This may be the reason for thrombosis and a lower patency rate after chemotherapy.