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Updated: Feb 10, 2026

Real-Time Imaging of CCL5-Induced Migration of Periosteal Skeletal Stem Cells in Mice

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Published on: September 16, 2020

Systemic mastocytosis with skeletal involvement.

R Casadei¹, R De Cristofaro, A Ferruzzi

¹1a Clinica Ortopedica dell'Università, Istituto Ortopedico Rizzoli, Bologna.

La Chirurgia Degli Organi Di Movimento

|July 1, 1991

Summary

This summary is machine-generated.

Systemic mastocytosis, a rare disease, presents with bone involvement. This review covers its classification, pathogenesis, radiographic and histological features, and differential diagnoses for better understanding.

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Area of Science:

Hematology
Oncology
Radiology

Background:

Systemic mastocytosis (SM) is a rare clonal myeloid neoplasm.
It is characterized by abnormal mast cell accumulation in various organs, including bone.
Bone involvement in SM can manifest with diverse clinical and radiographic findings.

Observation:

This review was prompted by a case of systemic mastocytosis with significant clinical and radiographic bone manifestations.
The case highlighted the need for a comprehensive understanding of bone involvement in SM.

Findings:

The literature review covers the current classification of systemic mastocytosis.
It details recent pathogenetic hypotheses related to SM.
Radiographic presentations, histological findings, and common differential diagnoses for bone involvement in SM are discussed.

Implications:

Accurate diagnosis and classification of systemic mastocytosis are crucial for patient management.
Understanding the diverse radiographic and histological features aids in differentiating SM from other bone diseases.
This review provides a consolidated resource for clinicians and researchers on systemic mastocytosis with bone involvement.