Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

Viral Hepatitis I: Introduction

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

Chickenpox

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...

Smallpox

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

Rabies

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Author Correction: Lyme borreliosis.

Nature reviews. Disease primers·2026

Same author

Lyme borreliosis.

Nature reviews. Disease primers·2026

Same author

Vectors are not just culture vessels.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Same author

Clinical data on symptomatic cutaneous reinfections due to Borrelia burgdorferi sensu lato in Slovenia.

Infection·2026

Same author

Xenodiagnosis to search for Borrelia burgdorferi after antibiotic treatment of Lyme disease: a prospective cohort study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

Same author

Guidance on the management of asymptomatic blood donors who test positive for Babesia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

Published on: October 11, 2022

Hepatitis in association with rickettsialpox.

Gul Madison¹, Leona Kim-Schluger, Susan Braverman

¹Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA.

Vector Borne and Zoonotic Diseases (Larchmont, N.Y.)

|January 4, 2008

Summary

This summary is machine-generated.

Rickettsialpox, a febrile illness caused by Rickettsia akari, can lead to acute hepatitis. This condition, transmitted by the Liponyssoides sanguineus mite, typically resolves completely in affected patients.

More Related Videos

Extraction of Saliva, Haemolymph, Salivary Glands, and Midgut from Individual Ticks (Acari: Ixodidae)

Extraction of Saliva, Haemolymph, Salivary Glands, and Midgut from Individual Ticks (Acari: Ixodidae)

Published on: October 31, 2025

Disclosing Hemolymph Collection and Inoculation of Metarhizium Blastospores into Rhipicephalus Microplus Ticks Towards Invertebrate Pathology Studies

Disclosing Hemolymph Collection and Inoculation of Metarhizium Blastospores into Rhipicephalus Microplus Ticks Towards Invertebrate Pathology Studies

Published on: June 1, 2019

Related Experiment Videos

Last Updated: Jul 8, 2026

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

Published on: October 11, 2022

Extraction of Saliva, Haemolymph, Salivary Glands, and Midgut from Individual Ticks (Acari: Ixodidae)

Extraction of Saliva, Haemolymph, Salivary Glands, and Midgut from Individual Ticks (Acari: Ixodidae)

Published on: October 31, 2025

Disclosing Hemolymph Collection and Inoculation of Metarhizium Blastospores into Rhipicephalus Microplus Ticks Towards Invertebrate Pathology Studies

Disclosing Hemolymph Collection and Inoculation of Metarhizium Blastospores into Rhipicephalus Microplus Ticks Towards Invertebrate Pathology Studies

Published on: June 1, 2019

Area of Science:

Infectious Diseases
Hepatology
Medical Entomology

Background:

Rickettsialpox is an acute, febrile illness caused by Rickettsia akari.
Transmission occurs via the mite Liponyssoides sanguineus, commonly found on house mice (Mus musculus).
Hepatitis is a known complication in some rickettsial infections, but its role in rickettsialpox is under-documented.

Observation:

This report details two patients diagnosed with rickettsialpox.
Both patients presented with acute hepatitis.
The hepatitis observed in these cases resolved entirely without lasting effects.

Findings:

Rickettsialpox can manifest with acute hepatitis.
The liver involvement associated with Rickettsia akari infection is reversible.
Complete resolution of hepatitis was observed in the described cases.

Implications:

Rickettsialpox should be considered in the differential diagnosis of acute hepatitis, especially in endemic areas.
Recognizing liver involvement in rickettsialpox is crucial for accurate diagnosis and management.
Further research may elucidate the mechanisms of hepatic involvement in Rickettsia akari infections.