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Carrier detection for X-linked agammaglobulinaemia (Bruton type) in an Irish family using linked DNA probes
W Reardon1, S Genet, H Middleton-Price
1I. Mothercare Department of Paediatric Genetics, Institute of Child Health, London.
Irish Medical Journal
|December 1, 1991
Abstract:
Being an X-linked condition, the sisters of men with X-linked agammaglobulinaemia have a 50% risk of being carriers of the disease gene (provided the disease has not developed as a results of a new mutation). We demonstrate how this risk can be modified very significantly by DNA analysis using linked DNA probes. The value of such tests for genetic purposes is discussed.