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Related Experiment Video

Updated: Jul 8, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

Transcriptome profile of human colorectal adenomas.

Jacob Sabates-Bellver1, Laurens G Van der Flier, Mariagrazia de Palo

  • 1Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

Molecular Cancer Research : MCR
|January 4, 2008
PubMed
Summary

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This summary is machine-generated.

Colorectal adenomas show significant gene expression changes, particularly in the Wnt pathway. KIAA1199 is identified as a novel Wnt target and potential marker for colorectal adenomatous transformation.

Area of Science:

  • Molecular biology
  • Gastroenterology
  • Oncology

Background:

  • Colorectal cancers often develop from adenomas, which are precancerous lesions.
  • Global gene expression changes during adenoma formation are not well understood.
  • Understanding these changes is crucial for early detection and treatment.

Purpose of the Study:

  • To characterize molecular processes in normal colonic epithelium transformation into adenomas.
  • To compare transcriptomes of normal mucosa and adenomas.
  • To identify key genes and pathways involved in colorectal tumorigenesis.

Main Methods:

  • Transcriptomic analysis of 32 prospectively collected colorectal adenomas and matched normal mucosa.
  • Comparison of gene expression profiles between normal, small adenoma, and large adenoma tissues.

Related Experiment Videos

Last Updated: Jul 8, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
15:17

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing

Published on: September 25, 2011

  • Analysis of Wnt signaling pathway components and targets.
  • Investigation of KIAA1199 expression patterns and regulation.

    • Main Results:

    • Significant differences in gene expression between normal and adenomatous tissues, and between small and large adenomas.
    • Extensive remodeling of the Wnt pathway, with altered expression of 78 components.
    • KIAA1199 expression is upregulated in adenomas and is a Wnt target.
    • KIAA1199 expression is reduced by inhibiting the beta-catenin/T-cell factor complex.

    Conclusions:

    • Transcriptomic profiles reveal insights into early colorectal tumorigenesis.
    • KIAA1199 is a novel Wnt signaling pathway target.
    • KIAA1199 may serve as a putative marker for colorectal adenomatous transformation.