Circulating colony stimulating factor-1 and breast cancer risk
Rulla M Tamimi1, Joan S Brugge, Matthew L Freedman
1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. rulla.tamimi@channing.harvard.edu
Cancer Research
|January 4, 2008
Summary
High levels of Colony Stimulating Factor-1 (CSF1) correlate with reduced premenopausal breast cancer risk but increased postmenopausal breast cancer risk. This suggests CSF1
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- Colony stimulating factor-1 (CSF1) and its receptor (CSF1-R) play roles in mammary gland development.
- These factors have been linked to breast carcinogenesis.
Purpose of the Study:
- To investigate the association between circulating CSF1 levels and breast cancer risk.
- To determine if this association varies by menopausal status.
Main Methods:
- Nested case-control study within the Nurses' Health Study.
- Prospective evaluation of CSF1 levels (measured 1989-1990) in 726 breast cancer cases and 734 matched controls.
- Analysis stratified by menopausal status.
Main Results:
- CSF1 levels showed a significant association with breast cancer risk that differed by menopausal status (P(heterogeneity) = 0.009).
- Highest quartile CSF1 levels were associated with an 85% reduced risk of premenopausal breast cancer (RR, 0.15; P(trend) = 0.02).
- Highest quartile CSF1 levels were associated with a 33% increased risk of postmenopausal breast cancer (RR, 1.33; P(trend) = 0.11), particularly for invasive and ER+/PR+ tumors.
Conclusions:
- The association between circulating CSF1 levels and breast cancer risk is dependent on menopausal status.
- CSF1 may have differential roles in premenopausal versus postmenopausal breast cancer development.
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