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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

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Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Gastritis-II: Pathophysiology

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Related Experiment Video

Updated: Jul 8, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Wegener's granulomatosis: the current view.

Frank Moosig1, Peter Lamprecht, Wolfgang L Gross

  • 1Department of Rheumatology, Vasculitis Center UKSH & Rheumaklinik Bad Bramstedt, University of Lübeck, Lübeck, Germany.

Clinical Reviews in Allergy & Immunology
|January 4, 2008
PubMed
Summary

Wegener's granulomatosis pathogenesis is better understood, including genetic factors and ANCA antibody roles. However, early granuloma formation triggers and the impact of biological therapies remain unclear.

Related Experiment Videos

Last Updated: Jul 8, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Immunology
  • Pathogenesis
  • Rheumatology

Background:

  • Wegener's granulomatosis pathogenesis research has advanced significantly.
  • Genetic risk factors and granuloma structure are increasingly understood.
  • The role of anti-neutrophil cytoplasmic antibodies (ANCA) in disease is clearer.

Purpose of the Study:

  • To summarize recent advancements in Wegener's granulomatosis pathogenesis.
  • To highlight areas of ongoing investigation, particularly initial disease events and therapeutic efficacy.

Main Methods:

  • Review of current literature on Wegener's granulomatosis.
  • Analysis of immunological and genetic findings.
  • Evaluation of therapeutic strategies, including biological agents.

Main Results:

  • Progress in understanding genetic predispositions and granuloma formation.
  • Clarification of the immunopathological pathways leading to PR3-ANCA induction.
  • Identification of knowledge gaps in initial granuloma development.

Conclusions:

  • While pathogenesis is better understood, the initial triggers for granuloma formation require further investigation.
  • The precise role and long-term efficacy of biological therapies like TNF-alpha-blockers and Rituximab in Wegener's granulomatosis need further definition.