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Neurotrophic factors in autonomic nervous system plasticity and dysfunction
1Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD. USA. mattsonm@grc.nia.nih.gov
Neuromolecular Medicine
|January 4, 2008
Summary
Neurotrophic factors regulate autonomic nervous system (ANS) neuron survival and function throughout life. These factors may mediate environmental impacts on the ANS and offer therapeutic potential for neurological disorders.
Area of Science:
- Neuroscience
- Autonomic Nervous System Physiology
Background:
- Neurotrophic factors are crucial for autonomic nervous system (ANS) neuron development and survival.
- Emerging evidence indicates neurotrophic factors influence adult ANS function and mediate environmental effects like exercise and diet.
Purpose of the Study:
- To review evidence for neurotrophic factor receptor expression on ANS neurons.
- To explore the role of neurotrophic factors in ANS plasticity and function.
Main Methods:
- Review of existing literature on neurotrophic factors and the ANS.
- Analysis of data on neurotrophic factor receptor expression and signaling in ANS neurons.
Main Results:
- ANS neurons express receptors for various neurotrophic factors, including brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factors, and ciliary neurotrophic factor.
- Activation of these receptors can modulate ANS plasticity.
Conclusions:
- Neurotrophic factors play significant roles in both the development and adult function of the ANS.
- Dysregulated neurotrophic factor signaling may contribute to ANS dysfunction in neurological disorders, suggesting potential therapeutic targets.
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