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Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

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Diffuse eosinophilic gastroenteropathy with pleural effusion and ascites.

Zlatko Hrgovic¹, D Bukovic, I Hirs

¹Department of Obstretics and Gynecology, J. J. Strossmeyer University, Clinical Hospital Osijek, Croatia. igorhr@t-online.de

Medicinski Arhiv

|January 5, 2008

Summary

A 39-year-old woman presented with constipation and flatulence. Diagnostic workup revealed eosinophilic gastroenteritis, characterized by eosinophilic granulocytes in the gastric wall and a mesenteric tumor mass.

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Area of Science:

Gastroenterology
Internal Medicine
Pathology

Background:

Eosinophilic gastroenteritis is a rare condition characterized by eosinophilic infiltration of the gastrointestinal tract.
Diagnosis can be challenging due to nonspecific symptoms and varied presentations.

Observation:

A 39-year-old woman presented with a 6-day history of constipation and flatulence, accompanied by a mild cough.
Imaging revealed right-sided pleural effusion and ascites.
Endoscopic and surgical evaluation identified eosinophilic granulocytes in the gastric wall and a solid tumor mass near the mesentery.

Findings:

Cytologic analysis of pleural effusion and ascites excluded malignancy.
Histopathological examination of the mesenteric mass revealed a significant presence of eosinophilic cells.
These findings collectively pointed towards a diagnosis of eosinophilic gastroenteritis.

Implications:

This case highlights the importance of considering eosinophilic gastroenteritis in patients with unexplained gastrointestinal symptoms and ascites.
The presence of a mesenteric mass with eosinophilic infiltration suggests a potential extraluminal manifestation of the disease.
Further research into the pathogenesis and optimal management of eosinophilic gastroenteritis, particularly with extraluminal involvement, is warranted.