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Updated: Jul 8, 2026
06:45
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
[Parkinson's syndrome--second life decade onset]
Rusmir Softić1, Omer C Ibrahimagić, Josip Hudić
1Klinika za psihijatriju, Univerzitetski klinicki centar Tuzla. rusmir@bih.net.ba
Medicinski Arhiv
|January 5, 2008
Summary
Juvenile parkinsonism is a rare condition affecting individuals under 20. Early diagnosis and treatment with dopamine agonists like Bromocriptine can significantly improve symptoms in young patients.
Area of Science:
- Neurology
- Pediatrics
- Movement Disorders
Background:
- Parkinsonism is uncommon in individuals under 40, with juvenile forms (under 20) being exceedingly rare.
- Affective and cognitive symptoms can precede motor deficits in juvenile parkinsonism.
Observation:
- A 16-year-old male presented with depression, anxiety, social withdrawal, and cognitive difficulties, followed by tremor and impaired balance.
- Neurological examination revealed extrapyramidal signs, including tremor and cogwheel rigidity.
- Standard laboratory and neuroradiological investigations were normal; however, visual evoked potentials showed left-sided lateralization.
Findings:
- Diagnosis of juvenile parkinsonism was established based on clinical presentation and neurological signs.
- Psychological evaluation indicated anxious personality traits, emotional sensitivity, and difficulties with mental control and memory.
- Treatment with a dopamine agonist (Bromocriptine) at 7.5 mg daily resulted in significant symptom reduction.
Implications:
- This case highlights the importance of considering rare forms of juvenile parkinsonism in the differential diagnosis of affective and cognitive disturbances in adolescents.
- Early intervention with dopaminergic therapy can effectively manage symptoms and improve quality of life in young patients with parkinsonism.
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