Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishing biochemical thresholds for serum metabolites to predict single or multiple production diseases in crossbred transition dairy cows under tropical climatic conditions.

Veterinary journal (London, England : 1997)·2026
Same author

Development of serum metabolite thresholds for early prediction of single or multiple production diseases in Sahiwal transition cows under tropical conditions.

Tropical animal health and production·2026
Same author

Modeling the impact of aerial water spray on the dynamics of anthropogenic pollutants to sustain industrialization.

Scientific reports·2026
Same author

A multiobjective optimal control problem for the dynamics of an infectious disease with limited healthcare facilities and vaccination.

Journal of mathematical biology·2026
Same author

A dynamical study to combat atmospheric pollutants using aerial water spray and sustain industrialization.

Chaos (Woodbury, N.Y.)·2025
Same author

Modeling the impact of temperature on the dynamics of carrier-dependent infectious diseases with control strategies.

Mathematical biosciences and engineering : MBE·2025

Related Experiment Video

Updated: Jul 8, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
07:14

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

Limbic encephalitis--an uncommon presentation of systemic malignancy.

K C Ghosh1, S Biswas, A K Misra

  • 1Department of Neuromedicine, Bangur Institute of Neurology, 52/1A, Shambhunath Pandit Street, Kolkata - 700 025.

The Journal of the Association of Physicians of India
|January 5, 2008
PubMed
Summary

A 46-year-old woman experienced neurological symptoms including seizures and behavioral changes. She was ultimately diagnosed with limbic encephalitis, a rare autoimmune disorder, secondary to lung adenocarcinoma.

Related Experiment Videos

Last Updated: Jul 8, 2026

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice
07:14

Minimally Invasive Cisterna Magna Injection Model for Leptomeningeal Metastasis Studies in Mice

Published on: May 23, 2025

Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Autoimmune limbic encephalitis is a rare neurological disorder.
  • Early diagnosis can be challenging due to non-specific symptoms.

Observation:

  • A 46-year-old woman presented with a three-month history of headache, vomiting, fever, behavioral changes, and seizures.
  • Clinical examination revealed meningism and bilateral papilledema.
  • Initial investigations including CSF analysis, normal brain CT, and chest X-ray findings suggested tuberculosis.

Findings:

  • Brain MRI demonstrated bilateral medial temporal lobe hyperintensities on T2 and FLAIR sequences, indicative of limbic encephalitis.
  • Despite empirical treatment for tuberculosis and herpes simplex encephalitis, the patient's condition worsened.
  • Subsequent investigations revealed adenocarcinoma of the lung, indicating a paraneoplastic syndrome.

Implications:

  • This case highlights the importance of considering paraneoplastic syndromes in the differential diagnosis of limbic encephalitis.
  • Early identification of underlying malignancy is crucial for effective management and improved patient outcomes.
  • Multidisciplinary collaboration between neurology, oncology, and radiology is essential for diagnosing and managing complex cases like this.