Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Regenerative Potential of Donkey and Human Milk on the Redox-Sensitive and Proliferative Signaling Pathways of Skin Fibroblasts.

Oxidative medicine and cellular longevity·2020

Same author

Microparticles expressing myeloperoxidase as potential biomarkers in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV).

Journal of molecular medicine (Berlin, Germany)·2020

Same author

Amendment of the OMERACT ultrasound definitions of joints' features in healthy children when using the DOPPLER technique.

Pediatric rheumatology online journal·2018

Same author

Educational recommendations for the conduct, content and format of EULAR musculoskeletal ultrasound Teaching the Teachers Courses.

RMD open·2015

Same author

EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice.

Annals of the rheumatic diseases·2015

Same author

The Effect of Ascorbic Acid on Mancozeb-Induced Toxicity in Rat Thymocytes.

Folia biologica·2015

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

[Bone marrow stromal damage mediated by immune response activity].

J Vojinović, B Kamenov, S Najman

Srpski Arhiv Za Celokupno Lekarstvo

|January 1, 1994

Summary

Activated immune responses can damage bone marrow microenvironment, impairing hematopoiesis. This leads to anemia and altered blood cell production in both experimental models and patients with chronic immune activation.

More Related Videos

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Related Experiment Videos

Last Updated: Jul 8, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

Published on: May 26, 2021

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia

Published on: November 10, 2023

Area of Science:

Immunology
Hematology
Cell Biology

Context:

Investigates the impact of immune system activation on blood cell formation (hematopoiesis).
Utilizes an experimental model of Bacillus Calmette-Guérin (BCG) immunized mice and human patients with chronic immune activation (infections, autoimmunity, malignancy).

Purpose:

To determine how an activated immune response influences hematopoiesis in vitro.
To correlate changes in bone marrow cultures and nitroblue tetrazolium (NBT) reduction with anemia and immune status.

Summary:

Activated macrophages, indicated by increased NBT reduction, contribute to bone marrow stroma damage.
Long-term bone marrow cultures revealed decreased hematopoietic cells, increased fibroblasts, and fat cell loss.
These changes correlated with anemia, leucocytosis, and stimulated myelopoiesis in peripheral blood.

Impact:

Demonstrates that immune activation can damage the bone marrow microenvironment, altering hematopoiesis.
Highlights the role of macrophage activation in bone marrow damage and associated hematological abnormalities.
Suggests that agents altering bone marrow extracellular matrix and cellularity can lead to microenvironmental damage and modified hematopoiesis.