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Adsorption Isotherms I

Adsorption Isotherms I

Adsorption isotherms are mathematical models that describe how molecules in a gas or liquid phase interact with surfaces. Two of the most common isotherm models are the Langmuir and Freundlich isotherms, which relate to Type I monolayer chemisorption. The Langmuir model is based on four key assumptions:• Adsorption cannot exceed monolayer coverage.• All surface sites are equivalent.• Molecules adsorb only at vacant sites.• There are no interactions between adsorbed molecules.Consider the...

Adsorption Isotherms II

Adsorption Isotherms II

Brunauer, Emmett, and Teller (BET) introduced a theory in 1938 that modified Langmuir's assumptions to explain multilayer physical adsorption. This theory is applicable to Type II isotherms and provides a more realistic picture of adsorption processes. The BET theory assumes a uniform solid surface with localized adsorption sites, where adsorption at one site doesn't affect adsorption at neighboring sites. This theory also allows for the possibility of additional molecules being adsorbed on top...

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Surface tension is defined as the force per unit length (γ) acting along the surface of a liquid. It arises due to strong intermolecular forces of attraction. A molecule located inside the bulk of the liquid is surrounded by other molecules and experiences equal forces in all directions. However, a molecule at the surface experiences unbalanced forces because there are more neighboring molecules below than above. This creates a net inward force that pulls surface molecules toward the interior,...

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Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

Clausius-Clapeyron Equation

Clausius-Clapeyron Equation

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Related Experiment Video

Updated: Jul 8, 2026

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Published on: June 14, 2016

Temperature dependence of mucin adsorption.

James McColl¹, Gleb E Yakubov, Jeremy J Ramsden

¹Department of Materials, Cranfield University, Bedfordshire MK43 0AL, UK.

Langmuir : the ACS Journal of Surfaces and Colloids

|January 5, 2008

Summary

This study reveals mucin glycoprotein

Area of Science:

Biophysics and Surface Chemistry

Background:

Mucin glycoproteins form dynamic surface coatings crucial for biological lubrication and protection.
Understanding mucin adsorption-desorption kinetics is key to elucidating their functional mechanisms.

Purpose of the Study:

To investigate the adsorption and desorption kinetics of mucin on a silica-like surface.
To determine the effect of temperature on mucin's conformational state and surface interaction energy.

Main Methods:

Kinetic measurements of mucin adsorption and desorption were performed.
Experiments were conducted across a temperature range of 25 to 60 degrees C.
Surface area occupied per molecule was analyzed at different temperatures.

Main Results:

Increasing temperature reduced the area occupied per mucin molecule in both bulk and adsorbed states.

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Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

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This indicates mucin belongs to the 'natively open' conformational class.

Desorption energy significantly increased with temperature due to conformational rearrangement.

Conclusions:

Mucin forms a regulated, temperature-invariant dynamic surface coating.
The observed conformational changes contribute to a stable interfacial layer despite temperature fluctuations.