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Updated: Jul 8, 2026

Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
Fluorescence enhancement in hot spots of AFM-designed gold nanoparticle sandwiches
Alpan Bek1, Reiner Jansen, Moritz Ringler
1Photonics and Optoelectronics Group, Physics Department and CENS, Ludwig-Maximilians-Universität München, Amalienstrasse 54, 80799 Munich, Germany.
Abstract:
We observe an enhancement of fluorescence from a single fluorescent sphere, which is sandwiched between two individual gold nanoparticles, forming a hot spot of strong field enhancement. The fluorescence enhancing hot spot is custom-designed by the deliberate assembly of gold nanoparticles with an atomic force microscope cantilever. The fluorescence intensity is monitored while the separation between the two gold nanoparticles is reduced by gradually pushing the gold nanoparticles closer to the fluorescent sphere. The fluorescence enhancement is maximal when the distance between the two gold nanoparticles is smallest, when the excitation polarization is parallel to the axis of the sandwich, and when the fluorescent sphere is positioned exactly on the axis connecting the two gold nanoparticles.
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