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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Verrucous tuberculid mimicking Kyrle disease.

Sujay Khandpur¹, Arika Bansal, M Ramam

¹Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. sujaykhandpur@yahoo.co.in

International Journal of Dermatology

|January 5, 2008

Summary

This study describes a rare verrucous tuberculid, a skin manifestation of tuberculosis. Diagnosis relies on identifying a deeper tuberculous infection and response to treatment, as the organism is hard to detect in skin lesions.

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Area of Science:

Dermatology
Infectious Diseases
Pathology

Background:

Cutaneous tuberculosis (TB) presents with diverse clinical variations influenced by pathogen virulence and host immunity.
Tuberculids, a specific form of cutaneous TB, pose diagnostic challenges due to difficulties in identifying Mycobacterium tuberculosis.
Diagnosis often relies on detecting a systemic TB focus and therapeutic response to anti-TB drugs.

Observation:

A 30-year-old male presented with a 4-year history of symmetrical verrucous papules, nodules, and plaques on the face, earlobes, and extremities.
Histopathology showed follicular plugs with caseating epithelioid granulomas, while PCR for Mycobacterium tuberculosis was negative.
Associated findings included axillary tubercular lymphadenitis and a strongly positive Mantoux reaction.

Findings:

The patient's lesions resolved completely with antitubercular therapy, confirming the diagnosis.
Clinicopathological features were unusual, mimicking Kyrle's disease.
The authors propose the term "verrucous tuberculid" for this distinct clinical entity.

Implications:

This case highlights the importance of considering tuberculids in the differential diagnosis of unusual skin conditions.
Successful treatment with antitubercular therapy underscores its efficacy in managing verrucous tuberculid.
Recognition of "verrucous tuberculid" can improve diagnostic accuracy and patient management for this rare form of cutaneous tuberculosis.