Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vitamin D lowers the number of intestinal tumours in adult intestine-specific Apc-mutant mice only during early tumour initiation in gestation and juvenility.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026

Same author

Beneficial health effects of ultraviolet radiation: expert review and conference report.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2025

Same author

A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL.

Scientific reports·2025

Same author

"Next top" mouse models advancing CTCL research.

Frontiers in cell and developmental biology·2024

Same author

Assessing the safety of new germicidal far-UVC technologies.

Photochemistry and photobiology·2023

Same author

Socs1-knockout in skin-resident CD4<sup>+</sup> T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides.

Biochemistry and biophysics reports·2023

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

UV-induced immunosuppression in the balance.

Frank R de Gruijl¹

¹Dermatology, Leiden University Medical Center, Leiden, The Netherlands. f.r.de_gruijl@lumc.nl

Photochemistry and Photobiology

|January 5, 2008

Summary

Ultraviolet radiation exposure causes systemic immunosuppression, a normal physiological response that may protect against sun allergies. This photoimmunology research explores UV effects on skin health and immune reactions.

Area of Science:

Immunology
Dermatology
Photobiology

Background:

Early experiments in hairless mice revealed UV-induced actinic keratoses and skin carcinomas occur systemically.
Margaret Kripke's foundational work in the 1970s explained this as UV-induced immunosuppression and tumor tolerance.
This led to the development of the field of Photoimmunology, expanding research into UV effects on carcinogenesis and infectious diseases.

Purpose of the Study:

Investigate the adverse effects of UV-induced immunosuppression on healthy individuals, prompted by ozone layer depletion concerns.
Explore the physiological role of UV-induced immunosuppression in humans.
Rekindle research into idiopathic polymorphic light eruption (sun allergy) by examining UV-induced immune responses.

Main Methods:

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Related Experiment Videos

Last Updated: Jul 8, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Utilized experiments with hairless mice to demonstrate systemic effects of UV radiation.

Reviewed foundational research in photoimmunology and UV carcinogenesis.

Incorporated findings on UV-induced immunosuppression in human subjects, including studies on idiopathic polymorphic light eruption.

Main Results:

UV-induced immunosuppression and tolerance toward UV-induced tumors were identified as key mechanisms.
UV exposure was found to induce immunosuppression in nearly all human subjects tested.
This immunosuppression may represent a protective physiological reaction against adverse immune responses in UV-exposed skin.

Conclusions:

UV-induced immunosuppression is a normal physiological response in humans, potentially protecting against conditions like sun allergy.
Photoimmunology research continues to elucidate the complex interactions between UV radiation, the immune system, and skin health.
Understanding these mechanisms is crucial for addressing the health impacts of ambient UV radiation and conditions like idiopathic polymorphic light eruption.