Sepsis associated encephalopathy
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Updated: Jul 8, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
1Lourdes Hospital, Kochi, Kerala, India.
Introduction:
Alteration of sensorium or an encephalopathy is a common diagnostic dilemma in critically ill patients and can be caused by a number of conditions. Sepsis associated encephalopathy (SAE) is now the most common encephalopathy encountered among intensive care unit (ICU) patients.
Definitions:
SAE is an encephalopathy attributed primarily to sepsis or systemic inflammatory response syndrome (SIRS) and has often been a diagnosis of exclusion.
Conclusion:
It is important to recognize SAE for its therapeutic and prognostic aspects. SAE worsens morbidity and mortality among ICU patients. Most therapeutic options center around aggressive treatment of the underlying infection.
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