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Updated: Jul 8, 2026
The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
Detection of the sentinel lymph node in breast cancer
Santosh K Somasundaram1, Dennis W Chicken, Mohammed R S Keshtgar
1Department of Surgery, Royal Free Hospital NHS Trust, Pond Street, London NW3 2QG, UK.
Introduction:
Axillary lymph node status for lymphatic staging in breast cancer is the best prognostic indicator and guides systemic treatment. Sentinel lymph node (SLN) biopsy is a novel, minimally invasive technique for lymphatic staging proven to improve quality of life. The accurate detection of the SLN is paramount for the success of the procedure.
Methods:
Relevant literature was reviewed with regards to the different dyes and techniques used for the detection of SLN in breast cancer.
Results:
Highest identification rates and lowest false negative rates are achieved by using the combined blue dye and radiocolloid technique with pre-operative imaging using a gamma camera. There is a well-recognized learning curve to successfully perform SLN biopsy.
Conclusions:
The concept of SLN has been well validated and is the standard of care in early breast cancer. A multidisciplinary approach and structured training is the key to the successful introduction of the technique.
