Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Diabetic Ketoacidosis l: Introduction01:25

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NOD1 is a key mediator of atrial myopathy in heart failure.

Theranostics·2026
Same author

Electrophysiological Effects of Right and Left Tragus Nerve Stimulation in Humans.

Circulation. Arrhythmia and electrophysiology·2026
Same author

Homozygous variant in LMF-1 identified in 3 Colombian families.

Journal of clinical lipidology·2026
Same author

Critical discrepancies in oximetry among patients with Raynaud's phenomenon.

Clinical rheumatology·2025
Same author

Atrial Myopathy and Heart Failure: Immunomolecular Mechanisms and Clinical Implications.

International journal of molecular sciences·2025
Same author

Use of intraoperative transsplenic injection of agitated saline to confirm temporary full attenuation of congenital extrahepatic portosystemic shunts in dogs.

Veterinary surgery : VS·2024

Related Experiment Video

Updated: Jul 8, 2026

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid
04:10

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid

Published on: March 8, 2024

Subacute presentation of propionic acidemia.

Carmen Delgado1, Carlos Macías, Maria de la Sierra García-Valdecasas

  • 1Department of Clinical Biochemistry, Virgen del Rocio University Hospital, Seville, Spain. cdpecellin@ole.com

Journal of Child Neurology
|January 5, 2008
PubMed
Summary

Propionic acidemia, a metabolic disorder, can present insidiously. Early diagnosis and dietary management, including protein restriction and specific supplements, significantly improved this patient's condition.

More Related Videos

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
06:06

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
11:47

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function

Published on: January 22, 2017

Related Experiment Videos

Last Updated: Jul 8, 2026

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid
04:10

A Porcine Model of Acute Respiratory Failure with a Continuous Infusion of Oleic Acid

Published on: March 8, 2024

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome
06:06

Oleic Acid-Injection in Pigs As a Model for Acute Respiratory Distress Syndrome

Published on: October 26, 2018

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
11:47

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function

Published on: January 22, 2017

Area of Science:

  • Biochemistry
  • Genetics
  • Pediatrics

Background:

  • Propionic acidemia is an inherited metabolic disorder.
  • It results from propionyl-CoA carboxylase deficiency, impairing amino acid and fatty acid catabolism.
  • This deficiency leads to toxic metabolite accumulation.

Observation:

  • A slow-onset propionic acidemia case was diagnosed at 9 months.
  • Cranial MRI revealed putaminal signal changes and restricted diffusion.
  • Biochemical and genetic tests confirmed the diagnosis.

Findings:

  • Treatment included a low-protein diet, carnitine, biotin, and specialized amino acid formula.
  • The patient showed improved hypotonia and weight gain.
  • Vomiting ceased and ketoacidosis resolved.

Implications:

  • This case highlights the importance of recognizing subtle presentations of propionic acidemia.
  • Timely diagnosis and comprehensive management are crucial for favorable outcomes.
  • Dietary interventions and supportive therapies can effectively manage metabolic decompensations.