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Association between hepatitis B surface antibody seropositivity and coronary artery disease

Alireza Amirzadegan1, Gholamreza Davoodi, Mohammad Ali Boroumand

  • 1Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran.

Indian Journal of Medical Sciences
|January 5, 2008
PubMed

Insights

Hepatitis B surface antibody seropositivity is not linked to coronary artery disease (CAD). This study found no significant correlation between HBV infection markers and CAD development or C-reactive protein levels.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Infectious agents are implicated in coronary atherosclerosis pathogenesis.
  • Hepatitis B virus (HBV) infection is prevalent in certain populations.

Purpose of the Study:

  • To assess the association between coronary artery disease (CAD) and hepatitis B surface antibody (HBS Ab) seropositivity.
  • To investigate the relationship between HBS Ab and C-reactive protein (CRP) levels in subjects undergoing coronary angiography.

Main Methods:

  • Cross-sectional study of 830 subjects undergoing coronary angiography.
  • HBS Ab status determined by ELISA; CAD assessed angiographically.
  • Statistical analysis included Chi-square, t-tests, and Pearson's Correlation Coefficient.

Main Results:

  • No significant difference in HBV seropositivity between patients with and without significant CAD (28.7% vs. 28.9%, P=0.954).
  • Mean CRP levels did not differ significantly between HBS Ab positive and negative subjects (10.77 vs. 10.33 mg/L, P=0.465).
  • CRP levels were significantly higher in the CAD group (P<0.001).

Conclusions:

  • Hepatitis B surface antibody seropositivity is not associated with coronary artery disease.
  • No significant linear correlation was found between HBS Ab and CRP levels.
  • CRP levels are elevated in patients with coronary artery disease, independent of HBV status.
Abstract

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