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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
Baseline Widal titres in healthy children.
Anand M Patil1, M L Kulkarni, Akhil M Kulkarni
1Department of Pediatrics, J.J.M. Medical College, Davangere, Karnataka, India.
Indian Journal of Pediatrics
|January 5, 2008
Summary
This study determined baseline Widal titres in healthy Davangere children. Most children showed low titres for Salmonella Typhi antigens, with higher titres observed in older children.
Area of Science:
- Medical Microbiology
- Epidemiology
- Immunology
Background:
- The Widal test is crucial for diagnosing typhoid fever.
- Establishing baseline Widal titres in healthy populations is essential for accurate serodiagnosis.
- Previous data on baseline Widal titres in children from Davangere is limited.
Purpose of the Study:
- To ascertain the baseline Widal agglutinin titres in apparently healthy children residing in Davangere.
- To provide reference values for Widal titres in a pediatric population.
Main Methods:
- A cross-sectional study was conducted involving 250 healthy children.
- Widal titres were determined using the standard tube agglutination test.
- Analysis included titres against 'O' and 'H' antigens of Salmonella enterica subsp. enterica ser. Typhi.
Main Results:
- A significant percentage of children (64.2% for 'O' antigen, 67.2% for 'H' antigen) had titres less than 1:20.
- Higher titres (1:40 and 1:80) were observed in a smaller proportion of children.
- Children aged 6 months to 2 years generally exhibited lower titres compared to older children.
Conclusions:
- Established baseline Widal titres for Salmonella Typhi antigens in healthy children from Davangere.
- Age-specific reference ranges were identified, with older children showing potentially higher baseline titres.
- These findings aid in the interpretation of Widal test results for typhoid fever diagnosis in this region.
