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Multicentric Castleman's disease in two cases.

Rajni Sharma1, Rachna Seth, V Thavaraj

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Pediatrics
|January 5, 2008
PubMed
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Castleman's disease, a rare lymphoproliferative disorder, presents in localized and multicentric forms. This study reports two pediatric cases from India, including one with asplenia, highlighting the disease

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Immunology

Background:

  • Castleman's disease is a rare lymphoproliferative disorder with localized and multicentric presentations.
  • Multicentric Castleman's disease (MCD) is aggressive, causing systemic illness and diffuse lymphadenopathy.
  • Pediatric MCD is exceptionally rare, with limited reported cases globally.

Observation:

  • This report details two pediatric cases of Castleman's disease from the Indian subcontinent.
  • One patient presented with multicentric Castleman's disease and asplenia.
  • Follow-up extended up to 44 months for the reported cases.

Findings:

  • The study contributes the first reported cases of Castleman's disease in Indian children.
  • The findings underscore the potential for MCD presentation in childhood, even with comorbidities like asplenia.

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  • Clinical course and management considerations for pediatric MCD are highlighted.

    • Implications:

    • This research expands the understanding of Castleman's disease epidemiology in pediatric populations.
    • It emphasizes the need for increased awareness and timely diagnosis of pediatric MCD, particularly in underrepresented regions.
    • Further research into the specific characteristics and treatment of childhood Castleman's disease is warranted.