Related Experiment Video
Updated: Jul 8, 2026

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
Published on: June 2, 2018
Mouse models for understanding the growth hormone insulin-like growth factor-I axis
1Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Me. 04401, USA. crosen@maine.maine.edu
Background:
Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass.
Conclusions:
Mouse models continue to deepen our understanding of IGF-I signaling and the role of IGF-I in determining marrow stromal cell fate.
Related Concept Videos
Insulin: The Receptor and Signaling Pathways
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Hypothalamic-Pituitary Axis
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
PI3K/mTOR/AKT Signaling Pathway
